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Landmark Papers in Anaesthesia

Tweet This issue’s review was kindly written by Dr David Melia, ST5 Anaesthesia & ICM, Bart’s and The London School of Anaesthesia. Landmark Papers in Anaesthesia consists of 19 chapters


Early anaesthesia prevents long-term stress and anxiety sensitivity

Early life pain alters neural circuits in the brain that regulate stress, suggesting pain experienced by infants who often do not receive analgesics while undergoing tests and treatment in neonatal


Using morphine after abdominal surgery may prolong pain

Using morphine to fight the pain associated with abdominal surgery may paradoxically prolong a patient’s suffering, doubling or even tripling the amount of time it takes to recover from the


Track pain medicines with brain imaging

A new study suggests a role for brain imaging in the assessment and potential treatment of chronic pain. University of Michigan researchers are the first to use brain imaging procedures


Treat pain with Botox

A team of 22 scientists from 11 research institutes led by Professor Bazbek Davletov, now at the University of Sheffield, created and characterised a new molecule that was able to


How propofol works

Researchers at Washington University School of Medicine in St Louis and Imperial College London have identified the site where propofol binds to receptors in the brain to sedate patients during


Propofol promotes regeneration of sciatic nerve

Propofol is a staple in the induction and maintenance of anaesthesia, because of its rapid and short-short acting effects. It can inhibit inflammation and suppress the secretion of the proinflammatory


Confusing results for long-lasting single-injection nerve blocks

A new liposomal bupivacaine product shows promise in providing long-lasting nerve block with a single injection, but authors also report some “confusing results” in Anesthesia & Analgesia. A single injection


‘Designer’ sedative for colonoscopy?

Developed using molecular-level techniques, the new ‘designer’ sedative drug remimazolam provides a promising new alternative for sedation in patients undergoing colonoscopy, reports a study in the journal Anesthesia & Analgesia.


Induced comas on autopilot

After suffering a traumatic brain injury, patients are often placed in a coma, which is induced with anaesthesia drugs, and can last for days. During that time, nurses must closely